Autoria: BERNARDI, B.; MALAFATTI, J. O. D.; MOREIRA, A. J.; NASCIMENTO, A. C. A.; LIMA, J. B.; VERMEERSCH, L. A. F.; PARIS, E. C.

Resumo: Multifunctional membranes applied to biomedical materials become attractive to support the biological agents and increase their properties. In this study, biopolymeric ?bers based on polycaprolactone (PCL) and pectin (PEC) were reinforced with faujasite zeolite (FAU) for cloxacillin antibiotic (CLX) loading. FAU with a high specific surface area (347 ± 8 m2 g?1 ), high crystallinity and particles with a diameter of up to 100 nm were produced under optimized synthesis conditions (100 °C/4 h). Zeolites were incorporated into polymeric nano?bers to be a cloxacillin (CLX) carrier in wound treatment, using electrospinning as an e?cient synthesis method. The ?bers produced showed good mechanical resistance and the ncorporation of CLX was proven by assays to inhibit the growth of Staphylococcus aureus bacteria. The controlled release of CLX in di?erent pH conditions, which simulate the wound environment, was carried out for up to 229 h, achieving a released CLX concentration of up to 6.18 ± 0.02 mg L?1 . These results prove that obtaining a hybrid fiber (polymer-zeolite) to incorporate drugs to be released in a controlled manner was successfully achieved. The bactericidal activity of this material shows that its use for measured applications could be an alternative to conventional methods.

Ano de publicação: 2025

Tipo de publicação: Artigo de periódico

Unidade: Embrapa Instrumentação

Palavras-chave: Antimicrobial, Electrospun, Faujasite, Polycaprolactone